Study of systemic sclerosis

The pathophysiology of these lung diseases is only partially understood because access to human lung tissue is restricted. Therefore, Professor Dinh-Xuan's team carries out its research on a mouse model in which systemic sclerosis is induced. The team has confirmed the involvement of nitric oxide in the pathophysiological processes of systemic sclerosis. Thus, the team hopes to study the severity of the pulmonary vascular disease and test for the presence of pulmonary arterial hypertension in the animal. The researchers also hope to assess the therapeutic effect of the activation or inhibition of key enzymes involved in the transmission of nitric oxide¹.