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Supported projects
View- France - La Pitié Salpêtrière Hospital
- India - French association Chaya
- India - Life Project 4 Youth
- India - Magic Bus
- Indie - Social Action for Value Education
- Morocco - Afoulki
- Philippines - Passerelles Numériques
- Philippines - Virlanie Foundation
- Senegal - Village Pilote Association
- Spain - Gil Gayarre Foundation
- Togo - ABEPE NGO
Study of systemic sclerosis
Pathophysiological study of a rare disease
Systemic sclerosis
Systemic sclerosis is a rare disease of unknown cause. The prevalence of this disease is on the rise. It is characterized by a progressive thickening of the skin and visceral organs, including the lungs. Two types of lung disease have been observed: diffuse interstitial lung disease, which is caused and made worse by pulmonary inflammation, and pulmonary arterial hypertension. These lung diseases are now the leading cause of systemic sclerosis-related mortality.
Poorly understood lung diseases
The pathophysiology of these lung diseases is only partially understood because access to human lung tissue is restricted. Therefore, Professor Dinh-Xuan's team carries out its research on a mouse model in which systemic sclerosis is induced. The team has confirmed the involvement of nitric oxide in the pathophysiological processes of systemic sclerosis. Thus, the team hopes to study the severity of the pulmonary vascular disease and test for the presence of pulmonary arterial hypertension in the animal. The researchers also hope to assess the therapeutic effect of the activation or inhibition of key enzymes involved in the transmission of nitric oxide1.
The Air Liquide Foundation's involvement
The Air Liquide Foundation is helping to fund the purchase of a device for measuring exhaled nitric oxide as well as the acquisition of the molecules and products necessary for the research. The Foundation has provided a €60,000 grant.
1 System for information transmission between cells
PROJECT IDENTITY
- Project initiator: Paris Descartes University and Cochin Hospital
- Location: Paris, France
- Year of support: 2015
- Manager R&D: Marc Lemaire, Air Liquide Healthcare International, Paris-Saclay Research Center